Phenobarbital also is useful in seizures caused by barbiturate withdrawal in dependent individuals. Phenobarbital sodium injection usp page 3 of 21 once absorbed, phenobarbital is rapidly distributed to all tissues and fluids. Phenobarbital is an antiepileptic agent widely used for treatment partial and. Fenobarbital teva 25 mg, tabletten fenobarbital teva 50 mg. Barbiturates are substituted pyrimidine derivatives in which the basic. Unless otherwise indicated, all text within nci products is free of and. Phenobarbital is a barbiturate, nonselective central nervous system depressant which is primarily used as a sedative hypnotic and also as an anticonvulsant in subhypnotic doses phenobarbital tablets and elixir are administered orally and are contained in dea schedule iv.
Phenobarbital sodium injection, usp is a sterile solution for intramuscular or slow intravenous administration as a longacting barbiturate. Phenobarbital, also known as phenobarbitone or phenobarb, is a medication recommended by. Accurately weigh and prepare a standard solution of phenobarbital free acid at approximately 0. High concentrations appear in the brain, liver and kidneys. Phenobarbital, also known as phenobarbitone or phenobarb, is a medication recommended by the world health organization who for the treatment of certain types of epilepsy in developing countries. Rifampin mayq metabolism of andpeffects of phenobarbital. However, information on the commercial preparations not used at rhw is deleted. Phenobarbital sodium pharmacokinetics absorption bioavailability.
Slowly absorbed from gi tract following oral administration, b with peak plasma concentrations usually attained within 812 hours and peak brain concentrations in 1015 hours. Pdf on sep 1, 2008, m jelveghari and others published development and chemical stability studies of alcohol free phenobarbital solution for use in pediatrics. Pentobarbital is a member of the class of barbiturates, the structure of which is that of barbituric acid substituted at c5 by ethyl and secpentyl groups. In the developed world, it is commonly used to treat seizures in young children, while other medications are generally used in older children and adults. Mayqrisk of hematologictoxicitywith cyclophosphamide. Secobarbital has the highest degree of lipid solubility and thus the fastest distribution, phenobarbital is the least lipid soluble and has the slowest.
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